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Weekly Round Up

Identification of key pathways and metabolic fingerprints of longevity in C. elegans

This post was originally published on this siteImpaired insulin/IGF-1 signaling (IIS) pathway and caloric restriction (CR) are two well-established interventions to prolong lifespan […]

Single-molecule fluorescent amplification of RNA using clampFISH probes

This post was originally published on this siteNon-enzymatic, high-gain signal amplification methods with single-cell, single-molecule resolution are in great need. We present a […]

Molecular basis of hemoglobin adaptation in the high-flying bar-headed goose

This post was originally published on this siteDuring adaptive phenotypic evolution, some selectively fixed mutations may be directly causative and others may be […]

Leveraging polygenic functional enrichment to improve GWAS power

This post was originally published on this siteFunctional genomics data has the potential to increase GWAS power by identifying SNPs that have a […]

iterative Random Forests to discover predictive and stable high order interactions

This post was originally published on this siteGenomics has revolutionized biology, enabling the interrogation of whole transcriptomes, genome- wide binding sites for proteins, […]

Dynamics of the upper airway microbiome in the pathogenesis of asthma-associated persistent wheeze in preschool children

This post was originally published on this siteRepeated cycles of infection-associated lower airway inflammation drives the pathogenesis of persistent wheezing disease in children. […]

Fronto-limbic dysconnectivity leads to impaired brain network controllability in young people with bipolar disorder and those at high genetic risk

This post was originally published on this siteRecent investigations have used diffusion-weighted imaging to reveal disturbances in the neurocircuitry that underlies cognitive-emotional control […]

Naked mole-rat transcriptome signatures of socially-suppressed sexual maturation and links of reproduction to aging

This post was originally published on this siteNaked mole-rats (NMRs) are eusocially organized in colonies with an extreme reproductive skew towards one pair […]

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