Antimicrobial Agents and Infectious Diseases

Possible New Treatment for Lassa Fever

Researchers led by a team from the University of Texas have developed a monoclonal antibody cocktail to treat Lassa fever that cured 100% of macaques infected with a fatal dose of Lassa, even if treatment was delayed until the primates were in advanced stages of the disease.  The cocktail, which is similar to ZMapp used to treat Ebola, is one of the few therapies for Lassa, which is endemic to the same countries in West Africa involved in the Ebola outbreak of 2014-2015.  There is no vaccine against Lassa fever at the current time.

The cocktail cross-reacted with all four clades of Lassa virus and was able to rescue all research subjects up to eight days after they were infected.

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